Ultra High Field Magnetic Resonance Imaging as a Biomarker for Premotor Parkinson's Disease

Oregon Health and Science University18 enrolled

Overview

This is a prospective observational study investigating the utility of 7 Tesla MRI to quantify nigrosome1 signal in a cohort of individuals with recent onset Parkinson's disease and in at-risk cohorts at a premotor state of Parkinson's disease.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Parkinson Disease REM Sleep Behavior Disorder

Interventions

MRIOTHER

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Idiopathic Parkinson's disease within 1 year of motor symptom onset. Idiopathic REM sleep behavior disorder without signs/symptoms of Parkinson's disease. Age-matched controls. Exclusion Criteria: * Atypical Parkinsonism * Contraindications for MRI

Locations (1)

Oregon Health & Science University

Portland, Oregon, United States

RECRUITING

Outcomes

Primary Outcomes

Quantitative signal analysis of nigrosome 1

Time frame: 1 year

Secondary Outcomes

Change in quantitative signal analysis of nigrosome 1

Time frame: 3 years

Central Contacts

Matthew Brodsky, MD

CONTACT

5034949054 brodskym@ohsu.edu

Data from ClinicalTrials.gov

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