Effects of DHA on Post-operative Fibrosis of Trabulectomy Blebs in Glaucoma Surgery

Centre Hospitalier Universitaire Dijon20 enrolled

Overview

Post-operative fibrosis of trabulectomy blebs is a major cause of surgical failure leading to a renewed increase in intraocular pressure. The use of anti-metabolites over many years has made it possible to improve success rates for this surgery but these drugs have numerous adverse effects as they are toxic. Alternative therapies are thus necessary, and we believe that DHA could have antifibrotic effects on fibroblasts and could thus improve success rates in this surgery.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Trabulectomy Deep Sclerectomy

Interventions

Samples of fibroblasts from Tenon's capsulePROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing trabulectomy or deep sclerectomy * Patients informed about the study Exclusion Criteria: \- Patients who refuse to take part in the study

Locations (1)

Chu Dijon Bourogne

Dijon, France

RECRUITING

Outcomes

Primary Outcomes

Test of cell viability by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide)

Time frame: At baseline

Test migration ability by video microscopy

Time frame: At baseline

Test proliferation with immunohistochemistry (Ki67 staining)

Time frame: At baseline

Analysis of cell cycle in flow cytometry

Time frame: At baseline

Central Contacts

Alain BRON

CONTACT

03 80 29 37 56 alain.bron@chu-dijon.fr

Data from ClinicalTrials.gov

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