Race-Specific Propofol Titration to Effect for Procedural Sedation

University of Florida2,780 enrolled

Overview

Prospectively evaluate newly established guidelines and make clinicians aware of inter-racial difference in propofol sensitivity.

The primary motivation in conducting this study is to conduct the implementation science, i.e., formalize and train, and retrain if needed, anesthesia providers in the standard practice of titrating infusion rate to effect and clinically evaluate the effect of race and ethnicity on propofol monotherapy sedation during GI endoscopy. The ultimate goal is to make it less likely that patients from races known to be sensitive to propofol experience inadvertent overdosing.

Study Type

OBSERVATIONAL

Enrollment

2,780

Conditions

Unconsciousness Apnea, Postanesthetic Sedative Overdose Hypoxemia

Interventions

Titrate propofol monotherapy infusion to effectPROCEDURE

Train anesthesia providers in a standardized protocol for titrating propofol infusion to effect.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing propofol sedation at Gainesville (GNV) and Jacksonville (JAX) GI Endoscopy suites * Age range 18 - 80 years old * Patients whose race can be identified from the electronic patient information chart (EPIC) Exclusion Criteria: * Patients who identify as multiracial in Epic * Patients who identify as Other in Epic * Patients who refuse to indicate their race in Epic * Patients whose race is listed as unknown in Epic

Locations (1)

UF Health

Gainesville, Florida, United States

Outcomes

Primary Outcomes

Change in the recovery times among races and ethnicities

Monitored using aggregate data for metrics of recovery times

Time frame: Change from baseline up to 24 hours

Data from ClinicalTrials.gov

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