Hyperoxemia can produce various complications including oxidative stress and myocardial injury. We hypothesized that the normoxic group would have lower myocardial injury compared to hyperoxic group after transcatheter aortic valve replacement.
Hyperoxemia can produce various complications, such as excessive oxidative stress, hyperoxia-induced vasoconstriction, increased perfusion heterogeneity, and resultant myocardial injury. Previous studies have been observed higher mortality in patient group maintained with supranormal oxygenation after resuscitation from cardiac arrest. However, the effect of hyperoxia vs. normoxia on myocardial injury during transcatheter aortic valve replacement (TAVR) has not been well investigated. We hypothesized that the normoxic group would have lower myocardial injury compared to hyperoxic group after TAVR.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
72
receives inspired oxygen fraction of 0.3
receives inspired oxygen fraction of 0.8
Seoul National University Hospital
Seoul, South Korea
Troponin I
Area under the curve of troponin I
Time frame: 72 hours after the end of procedure
CK MB
Area under the curve of CK MB
Time frame: 72 hours after the end of procedure
Changes in cerebral oximetry
changes in cerebral oximetry during the procedure
Time frame: through procedure completion, an average of 3 hours
Delirum
Newly onset delirium
Time frame: through admission completion, an average of 5 days
AKI or RRT
Newly onset acute kidney injury or renal replacement therapy
Time frame: through admission completion, an average of 5 days
stroke, myocardial infarction or mortality
Newly onset stroke, myocardial infarction or mortality
Time frame: through admission completion, an average of 5 days
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