Mesenchymal Stem Cells in Central Nervous System injury2017

Fuzhou General Hospital30 enrolled

Overview

Central nervous system (CNS) injury leads to morbidity in patients, which has few good rehabilitation measures. Mesenchymal stem cells seem to have regenerative and tissue-repairing capabilities. The investigators design this study to infuse mesenchymal stem cells (MSCs) intrathecally to CNS injury patients, and observe the safety and efficacy by recording the change of nervous system scores, trying to prove the effect of MSC in rehabilitate CNS injury.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Central Nervous System Injury

Interventions

UCMSCCDRUG

infusion of aUCMSC and conventional therapy

conventional treatmentDRUG

conventional treatment

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * CNS injury \> 3 months * age \> 18 years * willing to give consent * stable vital signs * absence of active infectcion Exclusion Criteria: * any contradiction to intrathecal infusion * age \< 18 years * CNS injury \< 3 months * CNS injury \> 3 years

Outcomes

Primary Outcomes

life quality score

Time frame: 1y

Secondary Outcomes

adverse events

Time frame: 1y

Data from ClinicalTrials.gov

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