D-0120 Safety and PK/PD, Food Effect Study in Healthy Volunteers

Inclusion Criteria: * Subjects must be medically documented as healthy and acceptable at physical examination. * Subjects serum uric acid level at screening ≥ 4.5 mg/dL. * Subjects must have a BMI between 18.0 and 30.0 kg/m2 and a body weight of 50 kg or higher * Subjects must have all laboratory parameters within the normal range or considered not clinically significant by the principal investigator. * Subjects must have a normal urinalysis, eGFR, ECG or results considered not clinically significant by the principal investigator. * Subjects are able to understand the study procedures and risks involved and must provide signed informed consent to participate in the study. Exclusion Criteria: * Any history or clinical manifestations of significant metabolic, hematological, pulmonary, cardiovascular, gastrointestinal, neurologic, hepatic, renal, urological, or psychiatric disorders. * Any history or suspicion of kidney stones. * Positive for HIV, Hepatitis B, and/or Hepatitis C. * Subjects who have used prescription drugs, over-the-counter drugs, or herbal remedies within 14 days before Day 1 of study medication dosing. * Undergone major surgery within 3 months prior to Day 1. * Women who are pregnant or breastfeeding. * Subjects who received any investigational test article within 5 half-lives or 30 days prior to Day 1 study medication dosing. * Subjects who consumed Seville oranges- or grapefruit-containing foods or beverages within 7 days before Day 1 and during the entire study duration. * Subjects with any condition that, in the judgment of the investigator, would place him/her at undue risk, or potentially compromise the results or interpretation of the study.