Topography-guided LASIK Surgery

Stanford University30 enrolled

Overview

The investigators are analyzing outcomes of topography-guided LASIK surgery in participants with myopia and myopic astigmatism

The investigators are analyzing outcomes of topography-guided LASIK surgery in participants with myopia and myopic astigmatism. The investigators will be monitoring changes in anterior segment optical coherence tomography epithelial thickness maps. The investigators will compare preoperative maps to postoperative maps at one, three, six and twelve months. In addition, the investigators will measure changes in epithelial maps from postoperative month through twelve months to help understand what is happening to the corneal epithelium to try to explain why UDVA and CDVA improves over time

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Myopia

Interventions

Topography-guided LASIKPROCEDURE

LASIK surgery

Eligibility

Sex: ALLMin age: 18 YearsMax age: 59 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects age 18 and older with healthy eyes. Nearsightedness between -0.50 diopters and -8.00 diopters. * Subjects with up to 3.00 diopters of astigmatism. * Subjects with a spherical equivalent of up to -9.00 diopters. Exclusion Criteria: * Subjects under the age of 18. * Subjects with excessively thin corneas. * Subjects with topographic evidence of keratoconus. * Subjects with ectatic eye disorders. * Subjects with autoimmune diseases. * Subjects who are pregnant or nursing. * Subjects with more than 3.00 diopters of astigmatism

Locations (1)

Byers Eye Institute at Stanford

Palo Alto, California, United States

Outcomes

Primary Outcomes

Epithelial thickness maps

Changes in anterior segment optical coherence tomography epithelial thickness maps.

Time frame: 12 months

Secondary Outcomes

Changes in corrected visual acuity

Corrected distance visual acuity (CDVA)

Time frame: 12 months

Uncorrected distance visual acuity

Uncorrected distance visual acuity (UDVA)

Time frame: 12 months

Quality of Vision

Patient reported outcomes questionnaire

Time frame: 12 months

Predictability

Percentage of eyes within +/-0.25, 0.50 and 1.00 diopter of the intended correction

Time frame: 12 months

Contrast visual acuity

5 and 25% ETDRS contrast acuity

Time frame: 12 months

Residual astigmatism levels after surgery

Vector analysis of astigmatic outcomes

Time frame: 12 months

Change in refraction over time

Change in spherical equivalent over time

Time frame: 12 months

Data from ClinicalTrials.gov

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