Progestrone and Doppler Indices

Kasr El Aini Hospital80 enrolled

Overview

The aim of our study is to assess the effect of vaginal progestrone on fetal and maternal doppler indices

A complete Doppler ﬂow assessment of the maternal and fetal circulation was conducted by an independent investigator blinded to the treatment, before and 48 hours after the ﬁrst administration of 400mg of vaginal progesterone, Voluson E8 (GE Healthcare, Zipf, Austria) ultrasound machine,equipped with a 3.5- MHz curvilinear abdominal transducer with color imaging capabilities, was used in all cases.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Preterm Labor

Interventions

A complete Doppler ﬂow assessment of the maternal and fetal circulationDIAGNOSTIC_TEST

A complete Doppler ﬂow assessment of the maternal and fetal circulation was conducted by an independent investigator blinded to the treatment, 48 hours after receiving 400mg of vaginal progestrone .Voluson E8 (GE Healthcare, Zipf, Austria) ultrasound machine ,equipped with a 3.5-MHz curvilinear abdominal transducer with color imaging capabilities, was used in all cases.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Gestational age: 18-33 weeks * Willing and able to give informed consent * History of preterm labor (\<34 weeks) * At risk for preterm labor ( increased amniotic fluid volume) * Short cervical length (\<25mm) as incidental finding * Presenting with actual cervical changes ( dilatation and\\or effacement) in current pregnancy Exclusion Criteria: * PPROM * Contraindication to progesterone use * Diabetic patients, have glucose intolerance * Multiple pregnancies

Locations (1)

Kasr El Ainiy Hospital

Cairo, Egypt

Outcomes

Primary Outcomes

change of ultrasound doppler indices.

A complete Doppler ﬂow assessment of the maternaland fetal circulation was conducted by an independent investigator blinded to the treatment, before and 48 hours after the ﬁrst administration of progesterone, Voluson E8 (GE Healthcare, Zipf, Austria) ultrasoundmachine,equippedwitha3.5-MHzcurvilinearabdominaltransducer with color imaging capabilities, was used in all cases.

Time frame: before and 48 hours after progestrone admistration

Data from ClinicalTrials.gov

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