Monitoring of Postoperative Residual Neuromuscular Blockade in Laparoscopic Surgery

Seoul National University Bundang Hospital80 enrolled

Overview

Compare the reversal effect of neostigmine and sugammadex using quantitative neuromuscular monitoring

At the end of surgery, decide the dosage of reversal referring to quantitative neuromuscular monitoring value (TOF). After the administration of reversal, the anesthesiologist who are going to manage the participant should not check the quantitative neuromuscular monitoring and determine the timing of extubation only with his (or her) judgement. After entering post-anaesthesia care unit (PACU) measure the TOF value and check the incidence of TOF ratio \> 0.9 between the neostigmine group and sugammadex group.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Enrollment

Conditions

Neuromuscular Block, Residual

Interventions

NeostigmineDRUG

Referring to the randomisation allocation program, participants allocated to group neostigmine, administrate neostigmine as reversal

SugammadexDRUG

Referring to the randomisation allocation program, participants allocated to group sugammadex, administrate sugammadex as reversal

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients aged over 18 years, planned to undergoing elective laparoscopic surgery under general anesthesia Exclusion Criteria: * Obesity BMI over 30 kg/m2 * Impairment of renal or/and liver function * Allergy to rocuronium, sugammadex * (Familial) history of malignant hyperthermia * Taking medicines which is affecting neuromuscular function

Locations (1)

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Outcomes

Primary Outcomes

the incidence of postoperative residual curarization

definition of postoperative residual curarization: TOF ration is 0.9 or over 0.9

Time frame: Immediately after entering PACU

Data from ClinicalTrials.gov

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