A randomized open labeled trial to compare the efficacy of antihistamine dosing-up and add-on treatment with H2-receptor antagonist in patients with chronic urticaria
* For four weeks * After the researcher confirms the selection / exclusion criteria on the baseline, the UAS, K-UCT, and CU-QoL are created and randomized from the subject. * Receive UAS, K-UCT, and CU-QoL from the subject during the last visit to assess safety
Study Type
OBSERVATIONAL
Enrollment
110
Ajou University Medical Hospital
Suwon, South Korea
Number of evaluation after 4 weeks treatment by a investigator
0-no effective, 1-ineffective, 2-effective, 3-no symptoms
Time frame: 4 weeks
Peripheral blood eosinophil count
in percentage
Time frame: 4 weeks
Number of evaluation as assessed by questionnaire
Sleepiness, dryness, dysuria
Time frame: 4 weeks
Number of urticaria control by K-UCT
Before and after treatment
Time frame: 4 weeks
Number of urticaria symptom by UAS
Urticaria activity score
Time frame: 4 weeks
Quality of life of chronic urticaria by CU-QoL
Quality of life questionnaire for patients with chronic urticaria
Time frame: 4 weeks
Number of Patient-controlled urticaria by VAS
evaluation of Patient-controlled urticaria
Time frame: 4 weeks
Number of patients using emergency medication
Emergency drug frequency in patients with chronic urticaria
Time frame: 4 weeks
Comparison of Serum total IgE
Comparison each group in treatment activity
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Time frame: 4 weeks
Number of physiological parameter
weight gain in kilograms
Time frame: 4 weeks
Number of creatinine, AST/ALT
Creatinine in mg/dl, AST/ALT in UL
Time frame: 4 weeks