The overall aim is to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality.
In this isocaloric clinical cross-over trial, the investigators aim to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality. The investigators intend to evaluate if changes in carbohydrate quantity and quality (including sugar) influence circulating even-chain saturated fatty acids or if fatty acid-derived indices of desaturation and de novo lipogenesis are more sensitive biomarkers of carbohydrate intake. By performing untargeted lipidomic analyses, the investigators aim to search for novel lipid biomarkers of carbohydrate quantity and quality. The investigators also want to evaluate the influence of moderate alterations of carbohydrate and sugar intake on lipoproteins, insulin sensitivity, inflammatory proteins.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
19
Diet low in carbohydrates (38%E), but higher in total and saturated fat.
Diet high in carbohydrates (53%E) and sugars, but low in wholegrain, rye and wheat fibre.
Diet high in carbohydrates (53%E), wholegrain, rye and wheat fibre, but low in sugars.
Uppsala univeristy hospital
Uppsala, Sweden
Palmitic acid in different plasma fractions
Measured by liquid gas chromatography (GC)
Time frame: 14-20 days
Even-chain saturated fatty acids (i.e. 14:0, 18:0) and monounsaturated fatty acids
Measured by liquid GC
Time frame: 14-20 days
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