Cannabidiol (CBD) is a bioactive cannabinoid compound in marijuana (cannabis sativa), but unlike Δ9 tetrahydrocannabinol (THC), lacks the psychoactivity effect of THC. Available evidence suggests that there are marked therapeutic CBD effects for diverse disease processes including inflammation, cancers, psychosis, and epileptic seizures. The purpose of this study, in both younger and older healthy humans, is to improve our understanding of how CBD might control and regulate blood vessel health as well as cognitive and exercise performance.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
24
Subjects will be administered in a double-blinded, randomized and cross-over design
University of British Columbia
Kelowna, Ontario, Canada
Circulating cannabidiol and nitric oxide markers
Measured by venous blood sampling
Time frame: Through study completion, an average of 1 year
Vascular function
Duplex ultrasound system
Time frame: Through study completion, an average of 1 year
Height
Height in cm
Time frame: Through study completion, an average of 1 year
Weight
Weight in kg
Time frame: Through study completion, an average of 1 year
Body mass index
Body mass in kilograms divided by height in meters squared
Time frame: Through study completion, an average of 1 year
Systolic blood pressure
Measured by automated sphygmomanometer
Time frame: Through study completion, an average of 1 year
Diastolic blood pressure
Measured by automated sphygmomanometer
Time frame: Through study completion, an average of 1 year
Heart rate
Measured by 3-lead electrocardiogram
Time frame: Through study completion, an average of 1 year
Respiration
Measured by spirometry
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Time frame: Through study completion, an average of 1 year
Medical History Questionnaire
Assesses inclusion/exclusion criteria and prior history of medical conditions.
Time frame: Through study completion, an average of 1 year
Gastrointestinal Distress Questionnaire
Measured using a 10 cm visual analogue scale
Time frame: Through study completion, an average of 1 year
Anxiety Questionnaire
Assessed with a visual analog scale
Time frame: Through study completion, an average of 1 year
Cognitive performance
Computerized battery of neuropsychological tests
Time frame: Through study completion, an average of 1 year
Exercise performance
Step-wise exercise test on cycle ergometer
Time frame: Through study completion, an average of 1 year