Development of Obesity and Bariatric Surgery

N/AEnrolling By InvitationNCT03296605

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School150 enrolled

Overview

This study focus on the cause of obesity and impacts of bariatric surgery on it.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Obesity

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Body mass index ≥18 kg/m2 2. already received bariatric surgery or abdonimal surgery Exclusion Criteria: 1. acute stroke or acute myocardial infarction in 6 months 2. autoimmune disease 3. long-term use of non-steroidal anti-inflammatory drugs, corticosteroids and immunosuppressive drugs 4. pregnancy 5. consists with other endocrine diseases 6. acute infection in2 weeks 7. cancer 8. use of antibiotics in 3 months 9. chronic digestive inflammations 9

Locations (1)

at Division of Endocrinology, the Affiliated Drum Tower Hospital of Nanjing University

Nanjing, Jiangsu, China

Outcomes

Primary Outcomes

Immunity cells

Ratio of immunity cells in circulating and adipose or liver tissue

Time frame: up to 5 years

Secondary Outcomes

Body weight and height

Body weight and height will be combined to report BMI in kg/m\^2

Time frame: up to 5 years

Insulin

Insulin (mIU/L) concentartions in serum and adipose tissue

Time frame: up to 5 years

Cytokine

Cytokines concentrations in circulating and adipose or liver tissue

Time frame: up to 5 years

Cognitive Assessment (MMSE)

Mini-Mental State Examination (MMSE) scores from 0-30, and the test means better cognition with a higher score.

Time frame: up to five years

Cognitive Assessment (MoCA)

The Montreal Cognitive Assessment (MoCA) scores from 0-30, and the test means better cognition with a higher score.

Time frame: up to 5 years

Cognitive Assessment (RBANS)

The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) scores from 0-800, and the test means better cognition with a higher score.

Time frame: up to 5 years

Cognitive Assessment (processing speed)

The Trial Making Test (TMT) provides a measure of processing speed, which consists of part A and part B (TMT-A and TMT-B). The time limits for performing the TMT-A and TMT-B are 180 and 300 seconds, respectively. Processing speed is estimated by the sum of the consuming time to complete TMT-A and TMT-B such that less time indicate faster processing speed.

Data from ClinicalTrials.gov

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Cognitive Assessment (executive function)

The Victoria Stroop Color-Word Test is a well-known measure of executive functioning. There are three indices including Stroop-dot, Stroop-word and Stroop-color word in the test. The color task consists of colored dots; the word task comprises ordinary words that are unrelated to the meaning of color; the color-word task consists of words written in color that indicate the meaning of the color, but the color of these words differs from the meaning of the word itself. The participants were asked to quickly read the color of the dots or Chinese words on the cards. The sum of consuming time taken to read the three cards is used as an index of executive function performance. Less time indicates better executive function.

Time frame: up to 5 years