Analysis of Stannous Fluoride in GCF and Subgingival Plaque

Inclusion Criteria: * Provide written informed consent to participate in the study; * Be 18 years of age or older; * Agree not to participate in any other oral/dental product studies during the course of this study; * Agree to delay any elective dentistry (including dental prophylaxis) until the study has been completed; * Agree to use the acclimation products and to refrain from using any other oral care products (including floss and mouth rinse) between the Acclimation and Baseline Visit; * Agree to use the treatment products and refrain from any form of non-specified oral hygiene during the treatment periods (after the Baseline Visit), including but not limited to the use of products such as floss, mouth rinse, or whitening products; * Agree to return for all scheduled visits and follow study procedures; * Must have at least 16 natural teeth; * Be in good general health, as determined by the Investigator/designee based on a review of the health history/update for participation in the study; * Agree to refrain from all oral hygiene after 11 p.m. the night prior to each visit; * Agree to refrain from eating, chewing gum, drinking and using tobacco for 4 hours prior to each visit; * Have minimum 20 sampling sites with bleeding and pocket depth ≥2mm but not deeper than 4mm. Exclusion Criteria: * Having a dental prophylaxis within 2 weeks of Acclimation visit; * Having rampant caries, open or untreated caries, or advanced periodontitis requiring prompt treatment; * A medical condition requiring an antibiotic prophylaxis prior to dental visits; * A history of hypersensitivity to oral care products containing stannous fluoride; or * Have any condition or disease, as determined by the Investigator/Designee based on a review of the medical history, which could be expected to interfere with examination procedures or with the subject's safe completion of the study.