The aim is to evaluate the effectiveness of three different regimens of prophylactic ondansetron on the incidence and severity of post-operative nausea and vomiting.
Patients will be randomize to one of three arms: 4mg ondansetron pre-emergence, 8 mg ondansetron pre-emergence, or 4mg ondansetron pre-incision followed by 4mg ondansetron pre-emergence. Primary outcome will be incidence of PONV in the PACU prior to discharge.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
141
dose as per arm selection
dose as per arm selection
Icahn School of Medicine at Mount Sinai
New York, New York, United States
Nausea Scale
Nausea Scale - full scale from 1-10, with higher score indicating more symptom of nausea
Time frame: average of 4 hours in PACU and POD1
Number of Participants With Episodes of Vomiting in the PACU
Number of participants with episodes of vomiting in the Post Anesthesia Care Unit
Time frame: average of 4 hours
Number of Participants With Symptoms on POD 1
Number of participants with symptom presence of nausea or vomiting or headache on post-operative day one
Time frame: Day 1
Number of Participants Who Needed Rescue Anti-emetics
Number participants who needed rescue anti-emetics, i.e,, additional treatments needed to control nausea or vomiting in the PACU
Time frame: average of 4 hours
Total Anesthesia Time
Time frame: intraoperative, up to 3.5 hours
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