INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI

Inclusion Criteria: * Ability to understand study procedures and to comply with them for the entire length of the study. Exclusion Criteria: * Patients who report that they are pregnant. * Patients with a positive urine pregnancy test * Patients with a history of renal transplantation. * Patients with bladder augmentation procedures using bowel. * Patients with poorly controlled Type II diabetes, Hgb A1C \>6.5% * Patients with spinal cord injury, ASIA Impairment Scale of C or higher. * Patients with pelvic surgery within 6 months. * Patients with urologic procedure within 6 months. * Patients with a history of reconstructive urologic surgery, such as reflux, congenital abnormality. * Immunocompromised patients being treated for malignancy or a history of actively treated malignancy within 5 years. * Patients with active systemic autoimmune disease. * Patients on systemic immunosuppression. * Use of antibiotic prophylaxis within 6 months * Use of antibiotics within 10 days of active infection * Allergy/sensitivity to gentamicin or nitrofurantoin. * Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements. * Inability or unwillingness of individual to give written informed consent.