The study will investigate Essential Tremor and Parkinson's Disease patients who underwent Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS). We will evaluate the effect of lesion characteristics on tremor and on quality of life after the procedure as compared with the baseline prior to the procedure.
The purpose of the study is to investigate the effect of lesion characteristics in ExAblate Transcranial Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) of the Vim thalamic nucleus. Clinical measures will be used to study patients suffering from medication-refractory tremor, Essential Tremor or idiopathic Parkinson's Disease. This study is designed as a prospective, observational, and clinical study. Assessments will be made before and after MRgFUS for; clinical tremor relief, quality of life (QoL) improvements, assessment of adverse events, and correlations of these measures with the size and shape of the lesion and the surrounding edema .
Study Type
OBSERVATIONAL
Enrollment
23
Clinical Rating Scale for Tremor
Tremor score: In ET patients - Clinical Rating Scale for Tremor (CRST)
Time frame: 3 MONTHS
Motor part of Unified PD Rating Scale
In PD patients - Motor part of Unified PD Rating Scale (UPDRS)
Time frame: 3 MONTHS
Quality of Life Essential Tremor Questionnaire
Quality of life: Quality of Life Essential Tremor Questionnaire (QUEST)
Time frame: 3 MONTHS
Parkinson's Disease Questionnaire
Parkinson's Disease Questionnaire (PDQ39)
Time frame: 3 MONTHS
iSeismometer application
For all patients: iSeismometer application for mobile phone for Assessment of tremor amplitude and frequency before and after the procedure.
Time frame: 3 MONTHS
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.