The Effects of Mood on Cerebral Perfusion

University Ghent48 enrolled

Overview

Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the effects of a different mood state (neutral, positive and negative mood), induced using subjects own memories, on both global and regional cerebral perfusion, measured with arterial spin labeling.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Cerebral Perfusion

Interventions

Mood induction (using own memories)BEHAVIORAL

Subjects deliver three positive, three negative and three neutral memories 30 seconds reliving a memory - answering questions about the memory - reliving memory for 2 minutes during ASL-MRI

Arterial spin labeling MRIDEVICE

Single PLD PCASL

Physiological monitoringDEVICE

During MRI: heart rate, end-tidal CO2, respiratory rate and skin conductance

Eligibility

Sex: ALLMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy university students * between 18 and 30 years old Exclusion Criteria: * No informed consent * Not using hormonal contraception * MRI-contraindications * Claustrophobia * Pregnancy * Chronic diseases and chronic medication use

Outcomes

Primary Outcomes

Regional Cerebral perfusion (ml/100g/min) during positive mood induction

Effect of positive mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.

Time frame: 2 minutes (ASL scan during mood state induction)

Regional Cerebral perfusion (ml/100g/min) during negative mood induction

Effect of negative mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.

Time frame: 2 minutes (ASL scan during mood state induction)

Regional Cerebral perfusion (ml/100g/min) during neutral mood induction

Effect of neutral mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.

Time frame: 2 minutes (ASL scan during mood state induction)

Regional Cerebral perfusion (ml/100g/min) after positive mood induction

Effect of positive mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.

Time frame: 2 minutes (ASL scan after mood state induction)

Regional Cerebral perfusion (ml/100g/min) after negative mood induction

Effect of negative mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.

Time frame: 2 minutes (ASL scan after mood state induction)

Regional Cerebral perfusion (ml/100g/min) after neutral mood induction

Effect of neutral mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.

Time frame: 2 minutes (ASL scan after mood state induction)

Data from ClinicalTrials.gov

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