Regional Haemodynamic Changes in Radial Artery Assessment With Continuous Pulsed-wave Doppler Ultrasound

China Medical University, China

Overview

The objective of the trial was to evaluate velocity-associated parameters of pulsed-wave Doppler ultrasound at induction, discharge from the post-anaesthesia care unit and during inspiratory cough in addition to the consumption of phenylephrine during the operation in patients undergoing video-assisted thoracic surgery with three types of anaesthesia management. The patients in this trial were visited during the entire operation and just before leaving the post-anaesthesia care unit. Velocity-associated data related to pulsed-wave Doppler ultrasound and the consumption of phenylephrine were collected.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Conditions

Lung Cancer

Interventions

0.5% ropivacaine paravertebral blockDRUG

The investigators designed a study to assess whether there were any blood flow indexes change during induction with doppler ultrasonography after 0.5% ropivacaine paravertebral block

0.25% ropivacaine epidural blockDRUG

A 4-5 ml bolus of 0.25% ropivacaine was administered 1 h after the initiation of TEB.

0.5% ropivacaine local anaesthesiaDRUG

local anaesthesia at the incision was induced by 0.5% ropivacaine by the surgeon just before the surgery.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. ethnic Chinese; 2. age, 18 to 65 years old; 3. American Society of Anaesthesiologists (ASA) physical status I or II; 4. required VATS for lung surgery and one lung ventilation . Exclusion Criteria: body mass index exceeding 30 kg/m2; Patients with a history of hypertension, diabetes mellitus or arteriosclerosis; and any allergy to drugs used in the study. Patients with arrhythmias or implanted cardiac pacemakers were excluded. Patients with diseases of the central or peripheral nervous system were excluded. Patients taking medications affecting the autonomic nervous system, such as b-blockers and calcium channel blockers

Locations (1)

the First Hospital of China Medical University

Shenyang, Liaoning, China

Outcomes

Primary Outcomes

The Change of end-diastolic velocity

The primary outcome was the end-diastolic velocity at 12 time points of anaesthesia induction among the three groups.

Time frame: baseline and 10 minutes after induction

Secondary Outcomes

pulsed-wave Doppler ultrasound

other data related to pulsed-wave Doppler ultrasound and acquired during anaesthesia induction, before leaving the PACU and during inspiratory cough

Time frame: before leaving the PACU, up to 5 minutes

intraoperative consumption of phenylephrine

Time frame: through study completion, an average of 3 hours

Data from ClinicalTrials.gov

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