Mitochondrial Metabolism and Hepatic Complications of Obesity

Nantes University Hospital

Overview

The study aims to characterize mitochondrial metabolism in the liver of obesity surgery patients and to study its relationships with hepatic steatosis, inflammation, and fibrosis.

The study aims to characterize mitochondrial metabolism in the liver of obesity surgery patients and to study its relationships with hepatic steatosis, inflammation, and fibrosis. The protocols involves a per-operative hepatic needle biopsy for mitochondria characterization and histological scoring of steatosis, inflammation, and fibrosis

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Conditions

Obesity

Interventions

liver biopsyOTHER

the biopsies will be performed under laparoscopy and taken in the lower part of the right hepatic lobe

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult men and women * affiliated to a social security * candidate for laparoscopic obesity surgery Exclusion Criteria: * Excessive alcohol consumption:\> 20 g / day (woman),\> 30 g / day (male) * Chronic viral hepatitis B or C * Genetic hemochromatosis * Taking the following drugs for at least 3 months up to 6 months before the scheduled date of obesity surgery: systemic corticosteroids, amiodarone, methotrexate * Wilson's disease * autoimmune hepatitis * alpha 1-antitrypsin deficiency * abetalipoproteinemia * Contraindications to liver biopsy

Outcomes

Primary Outcomes

Association between nonalcoholic steato-hepatitis and mitochondria morphological markers

Time frame: Until 6 month

Data from ClinicalTrials.gov

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