Brisk Walking Study in Nursing Home Residents

Clinique Mutualiste Chirurgicale de la Loire100 enrolled

Overview

It is well established that physical activity reduces the physiological effects of ageing. Among them, the decrease of the autonomic nervous system activity (ANS) is associated with the increase of cardiovascular events and sleep disorders occurence. It has been shown that high intensity cycle training can enhance the ANS activity by 30% in people aged of 70 years old. However, such trainings were done by old athletes used to train at intensities that could not be handled by nursing home elderly. Thus, an adapted activity such as brisk walking shall be defined to make it practicable for the many in convalescent homes. The investigators hypothesize that long term brisk walking training could lead to reactivate ANS in people living in convalescent homes.

The investigators aim to compare the effects of a 9 month brisk walking training (1 time a week or 3 times a week) on the ANS of nursing home residents.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Physical Activity Autonomic Nervous System Imbalance

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Being over 60 years old * Living in a nursing home of Mutualité Française de la Loire, France * Being able to walk without human aid * Being able to speak and write French * Being inactive (less than 1 hours of physical activity per week) * Having a normal sinus rhythm * Being affiliated to the social welfare system * Signing the informed consent form Exclusion Criteria: * Having serious balance disorders * Suffering from cardiac or respiratory pathologies that contraindicate physical activity * Serious comorbidities contraindicating physical activity * Diagnosed cardiac pathologies that prevent heart rate variability analysis: congestive heart failure, cardiac pacemaker, implantable cardioverter defibrillator, serious ventricular rhythm troubles, atrial fibrillation, atrial flutter. * Persons under legal protection

Outcomes

Primary Outcomes

SDNN value

Standard deviation of all normal nocturnal RR intervals

Time frame: 9 months

Secondary Outcomes

Heart rate variability parameters

Autonomic nervous system balance (RMSSD)

Time frame: 9 months

Heart rate variability parameters

Autonomic nervous system balance (LF/HF)

Time frame: 9 months

Heart rate variability parameters

Autonomic nervous system balance (Ptot)

Time frame: 9 months

Baroreflex sensitivity (BRS)

BRS slope variation measured at rest

Time frame: 9 months

Maximum oxygen uptake (VO2max)

Cardiopulmonary exercise testing

Time frame: 9 months

Daily physical activity

Actimetry (Actigraph-GT3X)

Time frame: 9 months

Daily physical activity

Adult physical activity questionnaire (APAQ)

Time frame: 9 months

Sedentary periods

Actimetry (Actigraph GT3X)

Time frame: 9 months

Sedentary periods

Adult physical activity questionnaire (APAQ)

Time frame: 9 months

Muscular force

Lower limbs maximum voluntary force test measured on force chair

Time frame: 9 months

Muscular endurance

Lower limbs endurance test measured on force chair

Time frame: 9 months

Muscular volume gains

Lower limbs muscular magnetic resonance imaging (MRI)

Time frame: 9 months

Plasmatic dosages of inflammatory molecules

CRP

Time frame: 9 months

Plasmatic dosages of inflammatory molecules

TNF alpha

Time frame: 9 months

Plasmatic dosages of inflammatory molecules

IL 17

Time frame: 9 months

Cognitive improvements

Neuropsychological evaluation with a neuropsychologist.

Time frame: 9 months

Quality of life

SF-36 questionnaire

Time frame: 9 months

Brisk Walking Study in Nursing Home Residents

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts