Overall Diet Quality and Breast Cancer Risk

University of California, Irvine96,959 enrolled

Overview

The purpose of this study was to examine the relationship between indices of overall diet quality and incident breast cancer risk in a large prospective cohort of women.

This study examined the role of overall diet quality on the risk of developing invasive breast cancer among 96,959 women in the California Teachers Study, in which 4,826 women were diagnosed with breast cancer during follow-up (1995-2011). Participants' dietary habits were recorded at baseline (1995) using a 103-item Block95 Food Frequency Questionnaire to allow for the assessment of overall diet quality. Specifically, diet quality was characterized by the Alternate Mediterranean Diet (aMED), Alternative Healthy Eating Index-2010 (AHEI-2010), Dietary Approaches to Stop Hypertension (DASH), and Paleolithic Index scores. Associations between diet quality and the risk of developing breast cancer were examined using multivariate Cox proportional hazard regression models to provide hazard ratios and corresponding 95% confidence intervals.

Study Type

OBSERVATIONAL

Enrollment

96,959

Conditions

Invasive Breast Cancer Incident Breast Cancer

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: * Participants with no history of cancer diagnosis prior to baseline. * Participants with no history of myocardial infarction prior to baseline. * Participants with no history of stroke prior to baseline. * Participants with no history of diabetes prior to baseline. * Participants who are not missing excessive dietary data. * Participants with energy intake values at ≥1% and ≤99% of the population distribution.

Outcomes

Primary Outcomes

Incident Invasive Breast Cancer

All incident cancer cases were identified through linkage with the California Cancer Registry (CCR) records, which is a population-based cancer registry for California residents.

Time frame: 1995-2011

Data from ClinicalTrials.gov

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