Metaplasticity Experimental Design and Comparison of Motor Outcome Measure Sensitivity to Change

University of New Mexico13 enrolled

Overview

The overall objective is to validate the methodology of a metaplasticity experimental design by assessing change in motor excitability after administration of priming transcranial direct current stimulation (tDCS) followed by repetitive transcranial magnetic stimulation (rTMS) in healthy human participants. Our primary objective is to compare pre- and post-measures of cortical excitability before priming tDCS (anodal, cathodal or sham) \[M1\], directly after priming tDCS \[M2\], directly after inhibitory rTMS \[M3\], and 10 minutes after inhibitory rTMS \[M4\]. Our secondary objective is to evaluate the sensitivity of motor excitability outcome measures response to the noninvasive neurostimulation (e.g. rTMS and tDCS). We also aim to compare pre- and post- measures of cortical excitability after inhibitory and excitatory priming of the motor cortex, and to evaluate the sensitivity of motor outcome measures to changes in cortical plasticity.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

rTMSDEVICE

Between time point M2 and M3, participant will receive 900 pulses of rTMS at 1Hz at 0.85 of M2 resting motor threshold.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 99 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Must be at least 18 years of age (all genders, races, ethnicity) * Must have no current psychiatric or neurologic issues * Must not have any conditions listed in exclusion criteria * Must be fluent in English Exclusion Criteria: * History of major psychiatric illness * Actively using neuropsychoactive medication * Legal or mental incompetency * Substance use disorder, abuse or dependence, with active use within the last three months * Significant medical or neurological illness * Prior neurosurgical illness * Prior neurosurgical procedure * History of seizure * History of ECT or TMS treatment within the past there months * Presence of a pacemaker, implanted medical pump or device, metal plate, or metal object in skull or eye (including shunts, dental implants, facial tattoos with metallic ink) * Pregnant women

Locations (1)

University of New Mexico

Albuquerque, New Mexico, United States

Outcomes

Primary Outcomes

Percent Change in MEP Amplitude

Percent Change in MEP amplitude over the first dorsal interosseous (FDI) muscle of the right hand

Time frame: assessed and reported throughout study completion pre- and post- intervention approximately 30 minutes

Secondary Outcomes

Cortical Silent Period

Change in length of CSP

Time frame: tDCS + rTMS assessed and reported pre and post (approximately 10 minutes)

Simple Reaction Time

Participants will perform a simple reaction time task. This will be measured in seconds of response after a stimulus. The final outcome will be percent change in the reaction time from pre- to post- intervention.

Time frame: The final outcome will be percent change in the reaction time from pre- to post- intervention.

Data from ClinicalTrials.gov

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