It's a multicentric, randomized, controlled study concerning 100 patients with treatment-resistant obsessive compulsive disorders (OCD). The aim of this study is to evaluate the effect of transcranial direct current stimulation (tDCS) on OCD patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
83
Patients will receive a tDCS stimulation during 30 mn with an intensity of 2 milliampere (mA).
Patients will receive a Sham stimulation during 30 mn
Hospices Civils De Lyon
Lyon, France
CHU de Nantes
Nantes, France
Centre Hospitalier Henri Laborit
Poitiers, France
C.H. Guillaume Regnier
Rennes, France
Yale Brown Obsessive Compulsive Scale (YBOCS) score
The primary objective of the study is to compare the change in Yale Brown Obsessive Compulsive Scale (YBOCS) scores from baseline to the week 2 (post-tDCS treatment) visit, between the two treatments groups
Time frame: 2 weeks
Yale Brown Obsessive Compulsive Scale (YBOCS)
i. Change from baseline to month 1 in Yale Brown Obsessive Compulsive Scale (YBOCS) scores, between treatment groups.
Time frame: Month 1
Yale Brown Obsessive Compulsive Scale (YBOCS),
ii. Response rate at month 3 in Yale Brown Obsessive Compulsive Scale (YBOCS) score from baseline, between treatment groups.
Time frame: Month 3
Clinical Global Impression (CGI)
Change from baseline to month 1 in above scales between treatment groups;
Time frame: Month 1
Clinical Global Impression (CGI)
Change from baseline to month 3 in above scales between treatment groups;
Time frame: Month 3
Brown Assessment of Beliefs Scale (BABS)
Change from baseline to month 1 in above scales between treatment groups;
Time frame: Month 1
Brown Assessment of Beliefs Scale (BABS)
Change from baseline to month 3 in above scales between treatment groups;
Time frame: Month 3
Brief Anxiety Scale (BAS)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Change from baseline to month 1 in above scales between treatment groups;
Time frame: Month 1
Brief Anxiety Scale (BAS)
Change from baseline to month 3 in above scales between treatment groups;
Time frame: Month 3
Montgomery and Asberg Depression Rating Scale (MADRS)
Change from baseline to month 1 in above scales between treatment groups;
Time frame: Month 1
Montgomery and Asberg Depression Rating Scale (MADRS)
Change from baseline to month 3 in above scales between treatment groups;
Time frame: Month 3
Hospital Anxiety and Depression scale (HAD)
Change from baseline to month 1 in above scales between treatment groups;
Time frame: Month 1
Hospital Anxiety and Depression scale (HAD)
Change from baseline to month 3 in above scales between treatment groups;
Time frame: Month 3
Sheehan Disability Scale, (SDS)
Change from baseline to month 1 in above scales between treatment groups;
Time frame: Month 1
Sheehan Disability Scale, (SDS)
Change from baseline to month 3 in above scales between treatment groups;
Time frame: Month 3