Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropriate firmness. In severe traumatic brain injury(TBI) patients, plasma fibrinogen concentrations decrease earlier and more frequently than other coagulation factors,predicting massive bleeding and death. The purpose of this study is to try early injection of fibrinogen concentrate in severe isolated traumatic brain injury and investigation the effect of it on post bleeding and complications.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
50
RiaSTAP, Fibrinogen Concentrate (Human) is a human blood coagulation factor indicated for the treatment of acute bleeding episodes. Dose (mg/kg body weight) = (\[Target level (mg/dL) - measured level (mg/dL)\])/(1.7 (mg/dL per mg/kg body weight))
Isfahan university of medical science.
Isfahan, Iran
RECRUITINGMortality rate.
Mortality rate after injection of fibrinogen concentrate.
Time frame: Until 90 days after admission.
Average of serum fibrinogen level.
Average of serum fibrinogen level in iTBI patient.
Time frame: Immediately after admission.
The effect of early fibrinogen on post trauma bleeding (Intracranial hemorrhage).
The need to packed cell, FFP, Platelete.
Time frame: 2, 6, 24, 72 hours and 30 , 90 days after admission.
The complications that related to fibrinogen concentrate.
like DVT, PTE, MI.by measurement of serum D-dimer for DVT and PTE and serum Troponin C for MI.
Time frame: until 90 days after admission.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.