Panomics Relationships in the Epidemiology of Cancer Through In Silico Expression (PRECISE)

Inclusion Criteria: * Patients with Family History of Cancer 1. Ages 18 or older 2. Either of the following: 1. Patients with two or more first, second or third degree blood relatives on the same side of the family diagnosed with cancer 2. Patients with one or more first, second or third degree blood relative with male breast cancer 3. Patients with a first, second, or third degree blood relative with a known BRCA1 or BRCA2 mutation 4. Patients with a first, second, or third degree blood relative who has had colorectal or endometrial cancer diagnosed before age 50 years 5. Patients with first degree relatives with a known deleterious APC, MEN1, MUTYH, PTEN, RET, STK11, TP53, or VHL gene mutation 6. Patients of Ashkenazi Jewish descent with one or more first degree relatives or two or more second degree relatives with breast, ovarian or colorectal cancer 3. The patient has signed the appropriate Institutional Review Board approved Informed Consent Form Patients with Clinical \& Environmental Risk Factors for Cancer <!-- --> 1. Either of the following: 1. Women 21 or older 2. Men 50-75 3. Men 75-85, with a history of smoking 2. At least one guideline recommended cancer screening test documented in the medical record, if indicated for age and gender (eg, pap smear, mammography, low dose chest CT and/or colonoscopy) 3. The patient has signed the appropriate Institutional Review Board approved Informed Consent Form Cancer Patients <!-- --> 1. Ages 18 or older 2. Either of the following: 1. New diagnosis of histologically confirmed cancer (any stage I-IV, as well as carcinoma in situ (CIS)), across multiple solid tumor types with no prior systemic cancer therapy and scheduled for surgical resection or non-surgical management 2. Or, subjects with a high suspicion for cancer diagnosis by clinical and radiological assessment, but without preceding histologic diagnosis, are eligible, if they have not received prior systemic cancer therapy and are scheduled for surgery 3. Has or will have a medically obtained pathological tumor specimen from core needle or surgical biopsy and/or surgical resection within 4 weeks (28 days) of study blood draw and pre-treatment 4. The patient has signed the appropriate Institutional Review Board approved Informed Consent Form Exclusion Criteria: * 1\. Blood or blood product transfusion in the preceding 2 months 2. Cognitive impairment as determined by clinical history 3. Pregnant women (by self-report of pregnancy status) 4. Inability to speak English 5. Previous diagnosis of cancer except: non-melanomatous skin cancer 6. Poor health status or unfit to tolerate blood draw