Hydroxychloroquine (HCQ) for Recurrent Pregnancy Loss

Inclusion Criteria: 1. ≥ 4 confirmed consecutive pregnancy losses prior to gestational age 22+0 in women with unexplained RPL 2. ≥ 3 confirmed consecutive pregnancy losses prior to gestational age 22+0 in women with unexplained RPL with minimum one second trimester loss. Exclusion Criteria: 1. Age below 18 years or above 39 at inclusion 2. Abnomal uterine anatomi at hysterosalpingography/hysteroscopy or hydrosonography 3. Chromosomal abnormalities within the couple 4. Menstrual cycle below 23 days or above 35 days 5. Lupusantikoagulans positivity or immunoglobulin (Ig)G/IgM anticardiolipinantibodies (≥10 GPL kU/l at Rigshospitalets Laboratorium) or plasma homocystein ≥25 mikrogr./l at repeated measurement with 12 weeks interval. 6. HIV or Hepatitis B or C positive 7. Psoriasis, retinopathy og serious imparied hearing (Contraindications for HCQ) 8. Chronic disease that lead to intake of immunemodulatory drugs or potentially pregnancy toxic agents 9. Hemoglobin ≤ 6.5 mmol/L, leukocytes \<3.5 E9/L, platelets \<145 E9/L at inclusion 10. Previous treatment with HCQ in pregnancy 11. \>1previous live birth 12. previous participation in this trial