FMRI Assessment After Radiofrequency in Trigeminal Neuralgia

Assiut University20 enrolled

Overview

To investigate the brain activations related to TN, using fMRI, and to evaluate changes in these activations following the application of pulsed and thermal Radiofrequency lesioning to the gasserien ganglion.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Trigeminal Neuralgia Pain, Neuropathic

Interventions

pulsed RadiofrequencyPROCEDURE

sensory stimulation will be carried out at 50 Hz. The definitive position of the electrode will be verified by inducing paresthesia with sensory stimulation between 0.1-0.3 V in the affected painful area, then pulsed radiofrequency will be applied for 10 patients for 10 mins

thermal RadiofrequencyPROCEDURE

sensory stimulation will be carried out at 50 Hz. The definitive position of the electrode will be verified by inducing paresthesia with sensory stimulation between 0.1-0.3 V in the affected painful area, then Thermal lesion will be applied for 10 patients for 2 cycles of 90 seconds

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 20 - 65 years * Primary trigeminal neuralgia * Maxillary and/or mandibular affection only * Failure of medical treatment Exclusion Criteria: * 2ry trigeminal neuralgia * Recurrent trigeminal neuralgia * Ophthalmic branch affection * Contraindication for intervention (sepsis, coagulopathy, infection at entery point, local anesthetic allergy,…) * Pregnancy

Outcomes

Primary Outcomes

pain alleviation

pain assessment by functional MRI

Time frame: 1 month

Data from ClinicalTrials.gov

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