Effect of Iron on Cerebral Dopamine Receptor Density in Non-anaemic Premenopausal Women With Low Ferritin and Fatigue

Inclusion Criteria: * Healthy female subjects, Age \> 18 years, premenopausal, regularly menstruating * BMI 18-25 kg/m2 * Serum ferritin level \< 15 μg/ml, Hb \> 120 g/L * Adequate contraception during the study period * Fatigue determined as 2 or more points in the basic questionnaire for fatigue * Informed consent Exclusion Criteria: * Day-night shift work * 11 or more points in the BDI * No psychiatric disease (as assessed by neuropsychiatric assessment) * 15 or more points in the ISI * Known hypersensitivity to iron carboxymaltose, iron sucrose or iron sulfate * Intake of iron preparations during the last 8 weeks before the start of the trial protocol * Pregnancy or lactation * Any cardiovascular or pulmonary disease * Acute or chronic infection/inflammation or malignancy * Other obvious physical or psychiatric causes for fatigue (known mental disorders, e.g. depression) * Chronic intake of concurrent medication (especially antipsychotic drugs), except oral contraceptives. Sporadic intake of NSAID or paracetamol, e.g. in the case of a common cold or sporadic headaches is allowed. * CRP \> 10 mg/L * TSH out of normal range * Any concurrent medical condition(s) that, in the view of the investigator, would prevent compliance or participation or jeopardize the health of the patients. * Participation in any other therapeutic trial within the previous month * Known History of HIV/HBV/HCV