Determinants of Formate Concentrations

Memorial University of Newfoundland1,701 enrolled

Overview

Formate is an important metabolite, serving as a donor of one-carbon groups to the intracellular tetrahydrofolate pool. However, little is known of its circulating concentrations or of their determinants. This study seeks to define formate levels and their determinants in a young, healthy population. Serum formate will be measured in 1701 subjects from the Trinity Student Study. The subjects, males and females, aged 18 to 28 years, were enrolled at Trinity College, Dublin. Formate levels will be compared with other one-carbon metabolites, vitamin status, potential formate precursors, genetic polymorphisms, and lifestyle factors.

Study Type

OBSERVATIONAL

Enrollment

1,701

Conditions

Healthy

Interventions

No InterventionOTHER

Cross-sectional study requiring a single serum sample

Eligibility

Sex: ALLMin age: 18 YearsMax age: 28 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Trinity College Dublin students with Irish grandparents Exclusion Criteria: * None

Outcomes

Primary Outcomes

Formate concentrations

Formate concentrations in study population

Time frame: Single baseline measurement; cross sectional, observational study

Data from ClinicalTrials.gov

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