The main purpose of this study is to compare the impact of aerobic interval training intensity on exercise adherence and changes in cardiorespiratory fitness, cardiometabolic risk profile, body composition, inflammatory markers and subjective health outcomes after a 12-week intervention trial in overweight individuals at increased cardiometabolic risk.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
154
Individualized, weight-reducing nutritional therapy and counseling, during a study period of 12 weeks
Procedures: Nutritional therapy (individualized, weightreducing nutritional therapy and counseling) during a study period of 12 weeks combined with supervised ergometer-based high-intensity interval training (HIIT). HIIT: * 2 sessions per week * 5x1 min at 80-95% HRmax * time-effort per week: \~30 min
Procedures: Nutritional therapy (individualized, weightreducing nutritional therapy and counseling) during a study period of 12 weeks combined with supervised ergometer-based moderate-intensity interval training on the basis of HRmax (MIIT-HR). MIIT-HR: * 2 sessions per week * 5x1 min at 65-79% HRmax * time-effort per week: \~30 min
Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports,
Erlangen, Germany
Cardiorespiratory Fitness (CRF)
CRF will be assessed by measuring Maximum Oxygen uptake (VO2max)
Time frame: 12 weeks (baseline to 12 week follow-up assessment)
Metabolic Syndrome Z-Score (MetS-Z-Score)
MetS-Z-Score will be calculated from each individual's measures of waist circumference, mean arterial blood pressure, triglycerides, and HDL-cholesterol, based on equations specific to sex.
Time frame: 12 weeks (baseline to 12 week follow-up assessment)
Body Composition
Muscle mass, fat mass and body water will be measured by Bioelectrical Impedance Analysis (BIA)
Time frame: 12 weeks (baseline to 12 week follow-up assessment)
Insulin sensitivity
Insulin sensitivity will be estimated using homeostasis model assessment index (HOMA)
Time frame: 12 weeks (baseline to 12 week follow-up assessment)
Inflammation
Inflammation will be assessed by measuring levels of inflammatory blood markers
Time frame: 12 weeks (baseline to 12 week follow-up assessment)
Health-related quality of life
Health-related quality of life will be assessed by using the standardized and validated EQ-5D-5L Questionnaire
Time frame: 12 weeks (baseline to 12 week follow-up assessment)
Pain scores
Pain scores will be assessed by using the standardized and validated Chronic Pain Grade Questionnaire (CPGQ)
Time frame: 12 weeks (baseline to 12 week follow-up assessment)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Procedures: Nutritional therapy (individualized, weightreducing nutritional therapy and counseling) during a study period of 12 weeks combined with supervised ergometer-based moderate-intensity interval training on the basis of lactate threshold (MIIT-LT). MIIT-LT: * 2 sessions per week * session 1: 2x4 min / session 2: 5x1 min, each at 105% LT * time-effort per week: \~30 min
Perceived stress
Perceived stress will be assessed by using the standardized and validated Perceived Stress Questionnaire (PSQ)
Time frame: 12 weeks (baseline to 12 week follow-up assessment)
Subjective work ability
Subjective work ability will be assessed by using the standardized and validated Work Ability Index Questionnaire (WAI)
Time frame: 12 weeks (baseline to 12 week follow-up assessment)