The purpose of this study is to provide a surveillance system to monitor changes in the rate of mother to child HIV transmission and preventive practices in France and especially to identify the occurrence of toxicity in children exposed perinatally to antiretroviral drugs.
The goal of the CO11 national cohort is to provide with CO1 a wider surveillance system to monitor changes in the rate of mother to child transmission and preventive practices in France and especially to identify the occurrence of toxicity in children exposed perinatally to antiretroviral drugs. The CO11 EPF enrolle HIV infected women who delivery in maternity generally smaller than CO1 maternity (15 sites in Paris area, 35 in mainland France and 4 in the DOM). Maternal clinical, biological and therapeutic data before and during pregnancy were collected at delivery, with simplified questionnaires. The children are examined clinically and biologically at birth, 6, 12 and 24 months.
Study Type
OBSERVATIONAL
Enrollment
5,200
Efficacy of PMTCT strategies by measuring rate of mother to child transmission of HIV
Number of infected children (HIV RNA \>50c/mL or Positive serology) reported on the total number of children
Time frame: At birth up to 24 months
Immuno-virological response during pregnancy
HIV ARN \<50c/mL, CD4 cells count\>500 cells/mL
Time frame: At inclusion up to childbirth
Tolerance and toxicity of different kind of MTCT prophylaxis during pregnancy
incidence of pathologies during pregnancy
Time frame: At inclusion up to childbirth
Impact of different kind of MTCT prophylaxis on childbirth
Childbirth mode (Number of emergency Caesarean section, Number of planned caesarean section)
Time frame: At delivery
Impact of different kind of MTCT prophylaxis during pregnancy on uninfected children
Clinical abnormalities (occurrence of adverse events)
Time frame: At childbirth, 1 month, 3 months, 6 months, 12 months and 18-24 months
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