In the stage of randomized controlled study, our purpose is to obtain the Intraoperative anticoagulation program supported by evidence-based medicine.
This study is divided into anticoagulation program in cerebral aneurysm with hybrid operation and anticoagulation program in cerebral arteriovenous malformations with hybrid operation two parts, and each part divide into two stage, on the stage of registration study. This study is a multi-center, single-blind, prospective cohort study. Record the patient's intraoperative activated coagulation time Changes in detail, to observe the effect of activated coagulation time maintenance level on hemorrhage event rate of Intraoperative and postoperative 48 hours, purpose to find out the safety range of activated coagulation time level in cerebral aneurysm and arteriovenous malformations with hybrid operation. On the stage of randomized controlled study. This study is a multicenter, single-blind, prospective, randomized controlled study. Patients is divided into intraoperative standard dose group of Heparin Sodium and low dose group of Heparin Sodium randomly. To observe the effect of different anticoagulation regimens on activated coagulation time safety coverage rate during surgery, and finally develop a scientific and effective intraoperative anticoagulant therapy program.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
408
Infused with 5000 IU of Heparin Sodium
Infusion Heparin Sodium at a rate of 18 IU / kg.h
Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China
RECRUITINGChanges in activated coagulation time safety coverage rate from the beginning of surgery to 48 hours after surgery
Activated coagulation time average value falls in the safety coverage rate from the beginning of surgery to 48 hours after surgery.
Time frame: From the beginning of surgery to 48 hours after surgery
Changes in hemorrhage event rate from the beginning of surgery to 48 hours after surgery
Hemorrhage event include intracranial hemorrhage caused by non-surgical reasons, as well as other organs or parts of the massive bleeding or small bleeding, Including subperitoneal hemorrhage, intraocular hemorrhage, gross hematuria, epistaxis time prolonged or repeated, gastrointestinal bleeding, hemoptysis, subconjunctival hemorrhage, hematoma greater than 5cm, bleeding difficult to control the and so on.
Time frame: From the beginning of surgery to 48 hours after surgery
Changes in ischemia event rate from the beginning of surgery to 48 hours after surgery
Ischemia event include Cerebral infarction and transient ischemic attack.
Time frame: From the beginning of surgery to 48 hours after surgery
Intraoperative blood loss
All the blood lost during the surgery should be collected and measured.
Time frame: From the beginning of surgery to 48 hours after surgery
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