Study on Efficacy and Safety of CaReSR-1S to Repair Cartilage Defects of the Knee

Inclusion Criteria: 1. Aged from 18 to 55 years old; 2. Diagnosed with isolated knee cartilage defects in condyles of femur by arthroscopy, and the longest diameter is 1.1-2.2cm. The degree of the cartilage defects is Outerbridge IV degree or III degree but approximate to IV degree; 3. Outerbridge degree of cartilage in the other articular facet ≤Ⅱ; 4. Normal lower limb mechanical force line (varus or valgum \< 5°); 5. Skeletal mature; 6. 18Kg/M2 ≤ BMI ≤ 30Kg/M2; 7. Agree to sign the informed consent form; 8. Can cooperate in a post-operative rehabilitation program. Exclusion Criteria: 1. Superficial cartilage defects; 2. Concomitant with subchondral bone defect; 3. Varus or valgum \> 5°; 4. Serious meniscus injury; 5. Fractures around the knee; 6. Cannot join in the post-operative rehabilitation program; 7. The contralateral lower-limb cannot stand weight-bearing; 8. A history of knee surgery within 6 months; 9. Secondary arthritis affecting cartilage; 10. Serious arthrocleisis; 11. Undergoing clinical trial; 12. Serious illness of the heart, lung, and other vital organs; 13. Liver function test equal to two times or greater than the upper normal limits; serum creatinine equal to two times or greater than the upper normal limit; 14. Have a contagious disease; 15. Allergic to the agents; 16. Lactating or pregnant women; 17. Serious neuropathy or mental disease; 18. Be addicted with drug or alcohol.