The primary objective of this research is to compare the rate of canine retraction following the osteoperforation and piezocorticision procedures in cases of first premolar extractions. The secondary objectives are to compare the second order movement of the canine (tipping), the amount of root resorption associated with the procedures, the inflammation process by measuring the inflammatory markers in the gingival crevicular fluid, the loss of posterior anchorage by measures on the cone beam computed tomography (CBCT) 3-dimensional radiograph and on the casts and to evaluate the pain level and the impact on quality of life following each procedure using the questionnaire of the visual analogue scale (VAS) of pain.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
17
The piezocorticision is a procedure that aims to accelerate the movement of teeth during an orthodontic treatment. It consists of a local anaesthesia followed by an incision of the buccal mucosa and an incision in the alveolar bone with a piezotome.
The osteoperforation is a procedure that aims to accelerate the movement of teeth during orthodontic treatment. It consists of a local anaesthesia followed by perforations of the buccal mucosa and alveolar bone using a specific osteoperforation tool.
Clinique d'orthodontie de l'Université de Montréal
Montreal, Quebec, Canada
Rate of canine retraction
The speed at which the canine is moved in the space of the extracted premolar.
Time frame: From the time of force application until the distal of the canine touches the mesial of the second premolar. We estimate the time frame to be up to 24 weeks. Measures will be taken at two week intervals.
Amount of tipping
The angulation of the long axis of the canine at the end of the retraction.
Time frame: The measure is taken when the distal of the canine touches the mesial of the second premolar. We estimate the time frame to be up to 24 weeks
Amount of root resorption
The total reduction in volume of the root of the canine caused by the canine retraction measured on the cone beam computed tomography.
Time frame: The measure is taken when the distal of the canine touches the mesial of the second premolar. We estimate the time frame to be up to 24 weeks
Amount of posterior loss of anchorage
Measure of the amount of anterior movement of the posterior teeth during the retraction of the canine.
Time frame: The measure is taken when the distal of the canine touches the mesial of the second premolar. We estimate the time frame to be up to 24 weeks
Concentration of IL-1 in the gingival fluid sample
Measure of the concentration of IL-I using the Luminex technique.
Time frame: Measures are taken immediately before the periodontal procedures, then at 1,3,8 weeks and when the distal of the canine touches the mesial surface of the second premolar which can take up to 24 weeks.
Concentration of receptor activator of nuclear factor kappa-B ligand (RANKL) in the gingival fluid sample
Measure of the concentration of RANKL using the Luminex technique.
Time frame: Measures are taken immediately before the periodontal procedures, then at 1,3,8 weeks and when the distal of the canine touches the mesial surface of the second premolar which can take up to 24 weeks.
Concentration of osteoprotegerin (OPG) in the gingival fluid sample
Measure of the concentration of OPG using the Luminex technique.
Time frame: Measures are taken immediately before the periodontal procedures, then at 1,3,8 weeks and when the distal of the canine touches the mesial surface of the second premolar which can take up to 24 weeks.
Level of pain
Measure of the level of pain using a visual analogue scale of pain questionnaire ranging from 0-10.
Time frame: Daily, for 7 days following extraction of premolars and piezocorticision and osteoperforation procedures
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