The goal of this study is to evaluate the role of intraoperative continous and intermittent neuromonitoring and intraoperative parathormone (PTH) to predict postoperative nerve morbidity and hypocalcemia.
Intraoperative PTH values and intraoperative continuous neuromonitoring will be collected prospectively in consecutive patients who undergo total thyroidectomy. Postoperative parathyroid morbidity and recurrent laryngeal nerve morbidity will be evaluated within 1 week after total thyroidectomy and at 1 year postoperatively. Other postoperative morbidity will be evaluated at 1 year postoperatively using validated classification.
Study Type
OBSERVATIONAL
Enrollment
1,000
CHU Nancy
Vandœuvre-lès-Nancy, France
RECRUITINGintraoperative parathormone values
parathormone in pg/mL
Time frame: intraoperative
postoperative hypocalcemia
calcium in mg/L
Time frame: within 1 week after thyroidectomy
postoperative hypoparathyroidism
parathormone in pg/mL
Time frame: within 1 week after thyroidectomy
permanent postoperative hypocalcemia
calcium in mg/L
Time frame: at one year after thyroidectomy
permanent postoperative hypoparathyroidism
parathormone in pg/mL
Time frame: at one year after thyroidectomy
laryngeal nerve palsy
continuous intraoperative neuromonitoring (\> 50% baseline values yes/no)
Time frame: during thyroidectomy
laryngeal nerve palsy
laryngoscopy (normal / palsy)
Time frame: within 1 week after thyroidectomy
laryngeal nerve palsy
laryngoscopy (normal / palsy)
Time frame: at one year after thyroidectomy
Postoperative complications other than outcomes from 1 to 8
Postoperative morbidity classification (using a Clavien-Dindo classification) postoperatively
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Time frame: at one year after thyroidectomy