Description of an Immune Activation Profile Linked to Insulin Resistance in Subjects Aged 55-69

Centre Hospitalier Universitaire de Nīmes158 enrolled

Overview

The aim of the study is to describe an immune activation profile of people at risk of insulin resistance based on a wide range of markers which will allow easy identification of patients at risk.

Study Type

OBSERVATIONAL

Enrollment

158

Conditions

Insulin Resistance Metabolic Syndrome X

Interventions

Blood testOTHER

6ml blood sample taken

Eligibility

Sex: ALLMin age: 55 YearsMax age: 69 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * The patient has been informed of the study, its objectives, constraints and the patient rights * The patient must have given their free and informed consent and signed the consent form * The patient is aged 55-69 Exclusion Criteria: * The subject is participating in an interventional category 1 study * The patient has participated in another category 1 interventional study in the last 3 months * The patient is in a period of exclusion determined by a previous study * The patient is under safeguard of justice or state guardianship * The subject refuses to sign the consent * The subject does not understand the information

Locations (2)

CHU Nimes

Nîmes, France

Centre d'examen de santé de la Sécurité Sociale de Nîmes

Nîmes, France

Outcomes

Primary Outcomes

Cluster of Differentiation 4 (CD4+) T cell subpopulations

immunosenescence; number/mm3

Time frame: Day 0

Cluster of Differentiation 8 (CD8+) T cell subpopulations

immunosenescence; number/mm3

Time frame: Day 0

B cell subpopulations

flow cytometry

Time frame: Day 0

Natural killer (NK) cell subpopulations

immunosenescence; number/mm3

Time frame: Day 0

sCD14 level

ng/ml, enzyme-linked immunosorbent assays (ELISA)

Time frame: Day 0

16 ribosomal ribonucleic acid (rRNA) levels

polymerase chain reaction (PCR); copies/µl

Time frame: Day 0

lipopolysaccharide (LPS)-binding protein level

ELISA; µg/mL

Time frame: Day 0

Intestinal Fatty Acid Binding Protein level

ELISA; pg/mL

Time frame: Day 0

Total cholesterol

mM/L

Time frame: Day 0

High Density Lipoprotein

mM/L

Time frame: Day 0

Data from ClinicalTrials.gov

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Description of an Immune Activation Profile Linked to Insulin Resistance in Subjects Aged 55-69

Overview

Conditions

Interventions

Eligibility

Locations (2)

Outcomes

Primary Outcomes

Secondary Outcomes