The investigators hypothesize that a dietary intervention aimed at increasing unsaturated fatty acids (UFA) consumption is feasible and has the potential to improve cardiorespiratory fitness, metabolic flexibility and glucose tolerance in symptomatic obese heart failure with preserved ejection fraction (HFpEF) patients.
Twelve obese HFpEF subjects with exercise intolerance (reduce cardiorespiratory fitness measured at maximal cardiopulmonary exercise test \[CPX\]) will be assigned to a single-arm open-label dietary intervention in which subjects are encouraged and financially supported to increase daily UFA consumption. The investigators will measure dietary compliance with a validated 24-hour dietary recall and with objective operator-independent biomarkers of UFA consumption. The investigators will also measure the effects of UFA supplementation on: metabolic flexibility, glucose tolerance and body composition. Participants will have the option to participate in overnight session in the whole indirect calorimeter room (WIC) at baseline and at the end of the study.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
16
Investigators will provide participant with detailed information about the consumption of food rich in unsaturated fatty acids (UFA) like extra-virgin olive oil, canola oil or mixed nuts, and they will provide specific recommendations based on the participant's diet. The investigators will follow up with a weekly phone call to assure that the dietary recommendations are clear and that the participants can integrate the suggestions into their daily diets.
Virginia Commonwealth University
Richmond, Virginia, United States
Change in 24-hour dietary recall
Measured with validated 24-hour dietary recall (non-self administered)
Time frame: Baseline to 12 weeks
Change in dietary compliance (biomarkers)
Measured by changes in biomarkers of unsaturated fatty acid consumption
Time frame: Baseline to 12 weeks
Change in metabolic flexibility
Area under the curve change of respiratory quotient measured during overnight stay for 14 hours in the WIC
Time frame: At baseline and 12 weeks
Change in body composition
Assessed by dual energy X-ray absorptiometry (DXA)
Time frame: At baseline and at 12 weeks
Change in glucose tolerance
Oral glucose tolerance test (OGTT) measures plasma glucose and insulin
Time frame: At baseline and at 12 weeks
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