Concomitant Association of Ultrafractionated Brain Irradiation - Temozolomide in Inoperable Primary Glioblastoma Multiforme

Inclusion Criteria: * giving their informed consent * having a supratentorial malignant glioma, either grade 4 of St. Anne/Mayo grading, or glioblastoma multiforme according to WHO classification * having an inoperable brain tumor (diagnosed by stereotactic biopsy) * having a general status, evaluated by Karnofsky scale, \>60 * having a life expectancy \>3 months * not having previously had a brain irradiation and/or adjuvant or neo-adjuvant chemotherapy * potentially having another cancer, if histology and clinical history are available for comparison * being able to take oral tablets * no HIV disease * satisfactory hematology, hepatic and renal functions: polymorphonuclear neutrophils \>1500/mm3, platelets \>100000/mm3, Hb \>8g/dl, creatinemia ≤1.5 times upper normal value, total bilirubin \<1.5 times upper normal value, ASAT and ALAT \<3 times upper normal value * for women of childbearing potential, a contraception is given Exclusion Criteria: * having an under tentorial malignant glioma (brain stem and/or cerebellum), grade 4 of St. Anne/Mayo grading * having a Karnofsky score \<60 * having a life expectancy \<3 months * having had a brain irradiation or an adjuvant or neoadjuvant chemotherapy * refusing any additional therapy * having a non-malignant but serious systemic disease or uncontrolled active infection * having a severe psychiatric disorder * not having signed the informed consent * pregnant or breastfeeding woman