Prospective observational study to determine predictors that related to cardiac troponin I (cTnI) release, malondialdehyde (MDA) and high sensitivity C Reactive Protein (hs-CRP) after Tour de Borobudur (TdB) 2017
Eligible Criteria: 1. minimum sample size of 80 men, non-athlete, participants of TdB 2. Classified into two groups: 160kms cycling and 100kms cycling participation 3. 25-55 years old 4. voluntary participate in the research 5. eligible in pre participatory physical examination and ECG test by the doctor 6. have no history of the previous acute coronary syndrome (ACS) Measurements: Interview for determining predictors of sports participation history, medical history, family medical history and Rate of Perceived Exertion Measurement and examination to determine: anthropometry parameters, clinical conditions (Systolic BP, Diastolic BP, hemoglobin levels, T-cholesterol and HDL-C levels, the intensity in cycling activities (mileage, velocity, duration, and time for resting), hemodynamic responses (average and maximum heart rate, Karvonen Index), and Hydration status Other outcome measurements; pre and post-TdB 2017 measurements of cTnI, MDA, and hs-CRP
Study Type
OBSERVATIONAL
Enrollment
94
Main exposure is long distance cycling touring (TdB/NC) consists of three groups; 140kms, 100kms, and 240kms (investigator did not give any treatment/intervention, just observed the cycling touring event)
Universitas Negeri Semarang
Semarang, Central Java, Indonesia
Cardiac Troponin I (cTnI)
specific protein to determine cardiac injury
Time frame: immediate after TdB 2017 cycling touring within less than 5 min
Malondialdehyde (MDA)
oxydative stress marker
Time frame: immediate after TdB 2017 cycling touring within less than 5 min
High Sensitivity C Reactive Protein (Hs-CRP)
a biomarker that represents the inflammation process
Time frame: immediate after TdB 2017 cycling touring within less than 5 min
Number of Participants With Pathological ECG Appearance
Number of Participants with Pathological ECG Appearance. Pathological ECG appearance was the results of the ECG test describing one of the pathological appearances in ECG i.e.: 1. The pathological rhythm which is may consist of Atrial Flutter, Atrial Fibrillation, Supraventricular Tachycardia, Ventricular Fibrillation, First Degree Heart Block, Second Degree Heart Block, Type 1 - Mobitz I, Second Degree Heart Block, Type 2 - Mobitz II, Third Degree Heart Block, or other pathological rhythm appearances 2. Pathological ST-segment i.e. ST elevation (early repolarization), or another form 3. Pathological U wave, and 4. other pathological appearances
Time frame: immediate after TdB 2017 cycling touring within less than 5 min
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