Aim of the study is to investigate genes regulating glucose and lipid metabolism in subjects whose glucose metabolism, lipid metabolism, blood flow, or body fat distribution has been measured using positron emission tomography (PET), magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS) or computed tomography (CT) as part of their previous participation in clinical trials conducted at Turku PET Centre. By combining information from PET, MRI, CT, proteomics, metabolomics and genetics analyses we aim to find connection between genetic variation and metabolic and cardiovascular disease.
The data is collected as a separate part of the clinical imaging study protocols using a separate inform consent approved by the local ethics committee. The participation for this study consists of drawing whole blood, serum and plasma samples for genetics, proteomics and metabolomics analyses. The results from these studies are combined with baseline data from the original clinical imaging studies to find connections between genetic variation, metabolism, blood flow and body fat distribution in a cross-sectional setting.
Study Type
OBSERVATIONAL
Enrollment
2,050
Turku PET Centre (Turku University Hospital)
Turku, Finland
RECRUITINGSkeletal muscle insulin sensitivity
Skeletal muscle glucose uptake during euglycemic-hyperinsulinemic clamp (µmol/kg tissue/min)
Time frame: Baseline
Whole body insulin sensitivity
Whole body glucose uptake during euglycemic-hyperinsulinemic clamp (µmol/kg body weight/min)
Time frame: Baseline
Visceral adipose tissue insulin sensitivity to glucose uptake
Visceral adipose tissue glucose uptake during euglycemic-hyperinsulinemic clamp (µmol/kg tissue/min)
Time frame: Baseline
Abdominal subcutaneous adipose tissue insulin sensitivity to glucose uptake
Abdominal subcutaneous adipose tissue glucose uptake during euglycemic-hyperinsulinemic clamp (µmol/kg tissue/min)
Time frame: Baseline
Brown adipose tissue insulin sensitivity
Brown adipose tissue glucose uptake during euglycemic-hyperinsulinemic clamp (µmol/kg tissue/min)
Time frame: Baseline
Brown adipose tissue glucose uptake during cold exposure
Brown adipose tissue glucose uptake during cold exposure (µmol/kg tissue/min)
Time frame: Baseline
Insulin sensitivity of adipose tissue lipolysis
Plasma free fatty acid concentration during euglycemic-hyperinsulinemic clamp (mmol/l)
Time frame: Baseline
Myocardial insulin sensitivity
Myocardial glucose uptake during euglycemic-hyperinsulinemic clamp (µmol/kg tissue/min)
Time frame: Baseline
Liver insulin sensitivity to glucose uptake
Liver glucose uptake during euglycemic-hyperinsulinemic clamp (µmol/kg tissue/min)
Time frame: Baseline
Endogenous glucose production
Endogenous glucose production during euglycemic-hyperinsulinemic clamp (µmol/kg body weight/min)
Time frame: Baseline
Brain insulin sensitivity to glucose uptake
Brain glucose uptake during euglycemic-hyperinsulinemic clamp (µmol/kg tissue/min)
Time frame: Baseline
Abdominal subcutaneous adipose tissue mass
Abdominal subcutaneous adipose tissue mass (kg)
Time frame: Baseline
Visceral adipose tissue mass
Visceral adipose tissue mass (kg)
Time frame: Baseline
Liver fat content
Liver fat percentage (%)
Time frame: Baseline
Myocardial fatty acid uptake
Myocardial fatty acid uptake at fasting state (µmol/kg tissue/min)
Time frame: Baseline
Liver fatty acid uptake
Liver fatty acid uptake at fasting state (µmol/kg tissue/min)
Time frame: Baseline
Abdominal subcutaneous adipose tissue fatty acid uptake
Abdominal subcutaneous adipose tissue fatty acid uptake at fasting state (µmol/kg tissue/min)
Time frame: Baseline
Visceral adipose tissue fatty acid uptake
Visceral adipose tissue fatty acid uptake at fasting state (µmol/kg tissue/min)
Time frame: Baseline
Brown adipose tissue fatty acid uptake at fasting state
Brown adipose tissue fatty acid uptake at fasting state (µmol/kg tissue/min)
Time frame: Baseline
Brown adipose tissue fatty acid uptake during cold exposure
Brown adipose tissue fatty acid uptake at cold exposure (µmol/kg tissue/min)
Time frame: Baseline
Skeletal muscle fatty acid uptake
Skeletal muscle fatty acid uptake at fasting state (µmol/kg tissue/min)
Time frame: Baseline
Coronary flow reserve
Ratio of myocardial blood flow maximum at stress (ml/g/min) vs. myocardial blood flow at rest (ml/g/min)
Time frame: Baseline
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