Pre-Oxygenation Techniques in Pregnancy

University of British Columbia40 enrolled

Overview

A trial comparing outcomes of two pre-oxygenation techniques in obstetric patients.

Pre-oxygenation is performed prior to general anesthesia to prevent hypoxia during airway management. It is typically performed using a standard tight-fitting face mask; however, recent advances in oxygenation have occurred through the use of trans-nasal oxygen delivery devices, such as OptiFlow. There is limited evidence of the use of OptiFlow in the pregnant patient, and as such, this study aims to show that OptiFlow is as effective at pre-oxygenation as a standard tight-fitting face-mask technique in the pregnant population.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Preoxygenation

Interventions

Face Mask preoxygenationDEVICE

Standard face mask preoxygenation.

OptiFlow preoxygenationDEVICE

Preoxygenation using transnasal humidified rapid insufflation ventilatory exchange (THRIVE).

Eligibility

Sex: FEMALEMin age: 19 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy (American Society of Anesthesiologists class 1 or 2), pregnant patients ≥36 weeks gestation scheduled for elective Cesarean delivery under neuraxial anesthesia. Exclusion Criteria: * Comorbidities likely to alter outcome of respiration and gas exchange. * Patients only able to breathe through their mouth. * Patients who are in active labour. * Patients unable to tolerate a face mask being held over their mouth and nose. * Patients with a Body Mass Index ≥40kg/m2. * Patients who are unable to give informed consent.

Locations (1)

BC Women's Hospital

Vancouver, British Columbia, Canada

Outcomes

Primary Outcomes

End Tidal Oxygen Concentration (ETO2) Following Tidal Volume Breathing Using Either Face Mask or OptiFlow

Concentration of oxygen at the end of a breath following 3 minutes of tidal volume breathing using either face mask or OptiFlow

Time frame: From baseline ETO2 concentration to the end of 3 minutes of tidal volume breathing

Secondary Outcomes

End Tidal Oxygen Concentration (ETO2) Following Vital Capacity Breaths Using Either Face Mask or OptiFlow

Concentration of oxygen at the end of a breath following 8 deep breaths using either face mask or OptiFlow

Time frame: From baseline ETO2 concentration to the end of 8 vital capacity breaths (approximately 3 minutes)

Data from ClinicalTrials.gov

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