LAAO With DAPT Versus Antithrombotic Therapy

Korea University Anam Hospital480 enrolled

Overview

This study will retrospectively review and compare clinical outcomes between left atrial appendage occlusion with dual antiplatelet therapy versus conventional antithrombotic therapy in patients with atrial fibrillation undergoing drug-eluting stent implantation.

Composite of stroke and major bleeding will be compared after adjusting those groups using inverse probability weighted model.

Study Type

OBSERVATIONAL

Enrollment

480

Conditions

Atrial Fibrillation Coronary Artery Disease

Interventions

ACP or WatchmanPROCEDURE

Left atrial appnedage occlusion using ACP or Watchman

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * patients with AF who underwent PCI and treated with LAAO and DAPT or conventional antithrombotic therapy Exclusion Criteria: \-

Outcomes

Primary Outcomes

Composite of stroke and major bleeding

Primary endpoint is a composite of stroke and major bleeding. Stroke is defined as ischemic cerebrovascular event included both transient ischemic attack and ischemic cerebral infarction. Major bleeding event was defined as moderate or severe bleeding according to the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries criteria.

Time frame: From date of index procedure until the date of primary endpoint occur or date of last follow up, whichever came first, assessed up to 50 months

Data from ClinicalTrials.gov

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