Determination of the "Tissue Transit Time" (TTT)

University Hospital Tuebingen119 enrolled

Overview

Determination of Tissue Transit Time (TTT) as a parameter with high prognostic value to predict the functional course of the differential renal function and the development of the differential renal function after pyeloplasty

The ureteropelvic junction obstruction occurs in around 13% of children with antenatally diagnosed hydronephrosis. It remains a controversial topic what prognostic factors may be predictive for deterioration of the differential renal function. The tissue transit time (TTT) in the 99mTc- MAG3 diuretic renogram seems to be a predictive factor for the deterioration of the differential renal function in these patients. We therefore analyze the tissue transit time in the 99mTc- MAG3 diuretic renogram in a prospective multicenter observational study to determine it as a prognostic and diagnostic factor. Aim of the study is to differentiate which children could be treated conservatively and which will benefit from operative pyeloplasty

Study Type

OBSERVATIONAL

Enrollment

119

Conditions

Renal Insufficiency, Acute

Interventions

Tissue Transit TimeDIAGNOSTIC_TEST

Determination of Tissue Transit Time as a prognostic and diagnostic factor

Eligibility

Sex: ALLMax age: 3 Months

Medical Language ↔ Plain English

Inclusion Criteria: * unilateral, isolated hydronephrosis \>= grade III (SFU) * age \<= 3 months Exclusion Criteria: * associated malformation of the urogenital tract * global kidney insufficiency proven by creatinine examination * prematurity * no informed consent

Locations (9)

Kinderchirurgische Klinik

Augsburg, Germany

Klinik für Kinderchirurgie und Kinderurologie

Bremen, Germany

Klinik für Kinderchirurgie und Kinderurologie

Dortmund, Germany

Kinderchirurgische Klinik

Karlsruhe, Germany

Outcomes

Primary Outcomes

Sensitivity and Specificity

Estimation of Sensitivity and Specificity of a delayed tissue transit time as a diagnostic factor concerning worsening of the differential renal function in patients with congenital ureteropelvic junction obstruction

Time frame: 3 to 6 months

Secondary Outcomes

Examination of ultrasound findings

Relationship between ultrasound findings and the development of the differential renal function

Time frame: 3 to 6 months

Examination of renal drainage

Relationship between initial quality of renal drainage and the development of the differential renal function

Time frame: 3 to 6 months

Examination of initial differential renal function

Relationship between initial differential renal function and the development of the differential renal function

Time frame: 3 to 6 months

Data from ClinicalTrials.gov

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