Berlin-Brandenburg Pregnancy Cohort

Charite University, Berlin, Germany1,580 enrolled

Overview

This study will investigate the interplay of different immune cells and placental cells as well as their potential for the development of pregnancy complications. In particular, the translation of the uteroplacental syndrome into a maternal syndrome, considered in the multifactorial pregnancy disorder preeclampsia, will be investigated. Immune cell subtypes are causally involved in the formation and translation of preeclampsia by inducing an endothelial dysfunction which leads to cardiovascular damage.

Study Type

OBSERVATIONAL

Enrollment

1,580

Conditions

Preeclampsia Pregnancy Complications Diabetes Mellitus in Pregnancy

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy pregnant women after giving informed consent * pregnant with diagnosis of preeclampsia, gestational hypertension or gestational diabetes Exclusion Criteria: * infections * alcohol and drug abuse * manifest and chronic diseases

Locations (1)

Outcomes

Primary Outcomes

T cell population content at the time of preeclampsia diagnosis compared to controls and verified by flow cytometry

Time frame: at the time of preeclampsia diagnosis compared to controls at the same time point in pregnancy