Post-Pregnancy Cardio Trial

Charite University, Berlin, Germany47 enrolled

Overview

Preeclampsia is a systemic pregnancy disorder and is associated with an increased cardiovascular risk later in life. This study will characterize myocardial tissue in patients after preeclampsia compared to controls and investigate potential functional and structural changes in the heart of preeclamptic women primarily with two methods: cardiovascular magnetic resonance imaging and echocardiography. A comparison between these two methods, where appropriate, is also envisaged.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Preeclampsia

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * postpartal window: 0.5 - 20 years * cases: diagnosis of preeclampsia during the index pregnancy * controls: age and BMI matched Exclusion Criteria: * metal implants * kidney insufficiency (GFR \< 30 ml/min/) * claustrophobia * contrast medium allergy * current pregnancy/ lactation * chronic hypertension (\> 140/90) * diagnosis of previous cardiovascular disease * body weight over 120 kg * big tattoos in thorax area

Locations (1)

Experimental and Clinical Research Center (ECRC)

Berlin, Germany

Outcomes

Primary Outcomes

any structural or functional change of the heart (combined outcome)

Combined outcome: myocardial fibrosis, edema, fat infiltrates, inflammation, reduced ejection fraction, hypertrophy