Effects of SGLT2 Inhibition on Myocardial Insulin Sensitivity

Inclusion Criteria: 1. Provision of informed consent prior to any study-specific procedures 2. Female or male subjects aged between 40 and 75 inclusive. Patients who have been surgically sterilized (hysterectomy or tubal-ligation) at least 12 months prior to screening, or are postmenopausal having had no regular menstrual bleeding for at least one (1) year prior to screening. Menopause will be confirmed by a plasma follicle stimulating hormone (FSH) level of \> 35 IU/mL at screening, or Women with childbearing potential willing not to initiate pregnancy during the course of the study, and non-nursing women. Men having relationships with women with childbearing potential willing not to procure a pregnancy during the course of the study; 3. Patients with type 2 diabetes 4. Patients with established, stable CAD, defined as ≥30% coronary stenosis in at least one major coronary vessel on invasive coronary angiography (ICA) or computed tomography angiography (CTA) performed within 12 months from screening and no indication to revascularization or with no evidence of critical restenosis, if previously subjected to percutaneous coronary intervention (PCI) (\>6months). 5. Patients with a clinical indication for 13N-ammonia PET-CT, as established by a cardiologist, nuclear medicine physician or diabetologist. 6. Patients with a body mass index (BMI) equal or greater than 25 kg/m2 but less than 35 kg/m2 \[BMI = Weight (kg) / Height squared (m2)\] 7. Patients with a HbA1c between 7.0% and 8.5%, according to the actual clinical conditions of the patients; 8. Patients with diabetes duration \<10 years; 9. Patients with stable medical therapy \[including other anti-hyperglycemic agents (see Table 1, section 5.2.1 for all therapies allowed, as per current standard treatment); pioglitazone and basal-bolus insulin treatment are excluded, as reported in the exclusion criteria 15\] for at least 3 months prior to the screening visit (including stable insulin dose defined as no variation more than 30% in daily insulin dose within the preceding 3 months. 10. Patients with Fasting C-peptide \> 1 ng/mL (0.33 nmol/L) at Visit 0 Exclusion Criteria: 1. Type 1 diabetes (as assessed by medical history); previous diagnosis of Latent Autoimmune Diabetes of Adults (LADA), and or not fulfilling inclusion criteria #10 2. History of diabetic ketoacidosis or hyperosmolar non-ketotic coma 3. NYHA class III or IV 4. Unstable angina 5. Previous re-vascularisation (either percutaneous coronary intervention or coronary artery bypass graft) in the last \<6 months before screening 6. Reduced left ventricular ejection fraction (≤ 50%) 7. Increased likelihood of developing diabetic ketoacidosis (history of DKA, alcohol consumption, volume depletion dehydration, clinical conditions causing diarrhea, vomit and anorexia) 8. Moderate to severe renal impairment (eGFR\<60 ml/min/1.73m2 as calculated by the modification of diet in renal disease \[MDRD\] equation or end-stage renal disease); overt proteinuria, defined as Spot urine Microalbumin/Cr ratio of \>300 mg/g at screening (Visit 0) 9. Severe liver dysfunction 10. Asthma 11. Uncontrolled blood pressure 12. Symptomatic tachy- or bradyarrhythmias 13. Previous acute myocardial infarction 14. Contraindications to adenosine: known hypersensitivity to adenosine or to any of the excipients; sick sinus syndrome, second or third degree atrio-ventricular block (except in patients with a functioning artificial pacemaker); chronic obstructive lung disease with evidence of bronchospasm (e.g. bronchial asthma ); long QT syndrome; severe hypotension; decompensated states of heart failure 15. Use of pioglitazone; use of loop diuretics; basal-bolus insulin therapy; use of systemic steroids less than 3 days prior to the screening visit (Visit 0) 16. Known hypersensitivity to the active substance or to any of the excipients in study drug 17. Inability to provide informed consent 18. Participation in another clinical study with an investigational product during the previous 30 days 19. Patients with history of breast, bladder and prostate cancer 20. Patients who will undergo surgical procedures 21. Patients with acute urinary tract infection 22. Patients with history of intolerance to galactose and lactose 23. Severe/uncontrolled medical conditions, causing liquid volume depletion