This study aims to investigate the effects of different volumes of combined training on fatigue, neuromuscular variables, morphological, cardiorespiratory capacity, functionality, and quality of life, in breast cancer (BCa) women undergoing primary treatment. Two thirds will be the intervention group that will perform combined training, while the other third will be the control group that will have physiotherapy sessions.
Although chemotherapy and radiation are mainstream treatment modalities, patients will often experience treatment-related side effects such as impairments to the neuromuscular and cardiovascular systems and reduction in quality of life (QoL).To date, numerous positive effects on neuromuscular and aerobic parameters in response to resistance and aerobic training have been reported when both training modalities were simultaneously performed (i.e. combined training - COMB) in BCa patients. However, there is a lack of data regarding the prescription of this modality in BCa patients, as the necessary dose of resistance training for significant improve in fatigue, neuromuscular, and quality of life. In this sense, no previous studies investigate the effect of different volumes of resistance training in BCa patients, providing important informations about the prescription in this clinical population.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
84
Resistance exercises performed with different volumes (i.e. one-single set and multiple-sets) and 20-25 minutes of aerobic exercise will be performed twice a week, during 12 weeks.
The usual care will be recommended to avoid systematic physical exercise for 3 months and will receive general clinical recommendations such as nutritional intake and lifestyle issues in their respective hospital.
Hospital Moinhos de Vento
Pôrto Alegre, Brazil
RECRUITINGUniversidade Federal do Rio Grande do Sul
Pôrto Alegre, Brazil
RECRUITINGNeuromuscular fatigue
Fatigue will be assessed by Fatigue index in isokinetic device.
Time frame: Changes from baseline are assessed after the intervention (week 13)
Subjective fatigue
Fatigue will be assessed by Piper fatigue scale (PFS). The PFS in its current form is composed of 22 numerically scaled, "0" to "10" items (i.e. 0, none fatigue; 10, severe fatigue) that measure four dimensions of subjective fatigue: behavioral/severity (6 items; # 2-7); affective meaning (5 items: # 8-12); sensory (5 items: # 13-17); and cognitive/mood (6 items: # 18-23). These 22 items are used to calculate the four sub-scale/dimensional scores and the total fatigue scores.
Time frame: Changes from baseline are assessed after the intervention (week 13)
Body composition
Body composition will be assessed by Dual-energy X-ray absorptiometry
Time frame: Changes from baseline are assessed after the intervention (week 13)
Muscle thickness
Muscle thickness will be assessed by ultrasound images of quadriceps femoris and biceps.
Time frame: Changes from baseline are assessed after the intervention (week 13)
Echo intensity
Echo intensity is a grey scale for analyze the image that ranging from 0 (black) to 255 (white), and will be assessed by ultrasound images of quadriceps femoris and biceps.
Time frame: Changes from baseline are assessed after the intervention (week 13)
VO2máx
VO2máx will be assessed by an incremental protocol in a cycle ergometer
Time frame: Changes from baseline are assessed after the intervention (week 13)
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Knee extension muscle strength
Knee extension muscle strength will be assessed by a bilateral 1-repetition maximum, reported in Kg.
Time frame: Changes from baseline are assessed after the intervention (week 13)
Unilateral vertical bench press muscle strength
Unilateral vertical bench press muscle strength will be assessed by an unilateral 1-repetition maximum on both sides, reported in Kg.
Time frame: Changes from baseline are assessed after the intervention (week 13)
Knee extension peak torque
Knee extension peak torque will be assessed by maximal voluntary isometric contraction on the right side, in a isokinetic dynamometer.
Time frame: Changes from baseline are assessed after the intervention (week 13)
Quality of life assessed by European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30+Br23
Quality of life will be assessed by European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30+Br23. The EORTIC is composed by 53 questions scaled "0" to "4", and "0" to "7". These 53 items are used to compute four domains (i.e. global, functions, symptoms, and BR23 functions).
Time frame: Changes from baseline are assessed after the intervention (week 13)
Functional Performance: Timed-up and go test
The timed-up-and-go requires an individual to stand up from a seated position in a chair, walk 2.44m, turn around a cone, walk back to the chair and sit down.
Time frame: Changes from baseline are assessed after the intervention (week 13)
Functional performance: 5-repetitions Sit-to-stand test
For the 5-repetition sit-to-stand test, participants are instructed to start the test in a seated position with arms folded across the chest. After the start command, participants stand up until full knees extension and then back to a seated position. The time is stopped when the participants touch the seat after five complete repetitions.
Time frame: Changes from baseline are assessed after the intervention (week 13)
Functional performance: 30-seconds arm-curl
The arm-curl test determines the maximal number of times a 2kg dumbbell can be lifted with the dominant arm through elbow flexion in 30 seconds. Participants start the test seated in a chair, with arms extended and forearm maintained in supinated position during full range of motion.
Time frame: Changes from baseline are assessed after the intervention (week 13)
Functional Performance: Stair Climbing
For the stair-climbing test, participants are instructed to climb a 10-step staircase without skip steps or using the handrail (except in need of balance to prevent falls
Time frame: Changes from baseline are assessed after the intervention (week 13)