Pregnancy, Nitrate, Endothelial Function and Tissue Oxygen Saturation

Universidade Federal do Rio de Janeiro12 enrolled

Overview

Adequate macro and microvascular endothelial function during pregnancy is essential for the normal placental development and growing fetus. Beetroot juice (BJ) promotes improvement ins this parameters in no-pregnant individuals, however the beneficial effect did not avaliated in pregnant. The present study evaluated effects of BJ on macro and microvascular endothelial function in pregnant. Twelve pregnant were submitted to BJ and nitrate-depleted juice (PLA) interventions. Brachial flow-mediated dilation (FMD) and muscle oxygenation were measured 120 min after interventions. Urinary nitrate, nitrite were measured at baseline and 120 min after interventions.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Pregnancy

Interventions

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * gestation between 20 and 35 weeks; * over 18 years Exclusion Criteria: * diabetes mellitus and gestational diabetes; * hypertensive syndromes; * HIV positive; * liver or kidney disease; * beetroot allergy; * use of antioxidants and medicament that alter endothelial function; * use of antibiotics up to 2 weeks before the visits and using.

Outcomes

Primary Outcomes

Macro endothelial function

Flow-mediated dilation (FMD)

Time frame: Evaluated 120 minutes after the nutritional intervention

Micro endothelial function

Tissue oxygen saturation parameters

Time frame: Evaluated 140 minutes after the nutritional intervention

Nitrate urinary

Time frame: Evaluated 150 minutes after the nutritional intervention