Sequential Therapy With WLL/Inhaling GM-CSF for Autoimmune Pulmonary Alveolar Proteinosis

Inclusion Criteria: * Comfirmed diagnosis of autoimmune pulmonary alveolar proteinosis * Disease severity score (DSS) is 4-5 Exclusion Criteria: * The acute respiratory infection * Heart failure (such as cardiogenic pulmonary edema) * The serious liver and kidney dysfunction (creatinine or ALT were equal to or more than 2 times of the upper limit of normal range); * Pregnancy; * The patients with hereditary and secondary factors (inhalation of dust, hematological diseases, autoimmune diseases, etc.); * DSS is 1-3; * The patient is allergic to the drugs that be used in our research; * The patients with poor compliance, or suffering from mental illness; * The patients have not signed informed consent; * They were treated with whole lung lavage or regular GM-CSF therapy (treatment for more than 2 weeks) within 3 months before the enrollment.